For 25 years my DH was a gentle, caring lover who always was adamant about meeting my "needs" even though he had some issues with ED which was probably caused by the ADs. I think this is part of the reason he stopped taking the meds. He was off of them for about a year before he suddenly decided to fill his prescription. My DH too became hypersexual for awhile once he started taking his Zoloft again. He only stayed on the Zoloft for a month before he stopped. This was a month before his mother died. Then right after his mother died and before his big meltdown (aka the hospitalization) he started to say that he just couldn't "do it" Hope this isn't too graphic...but he would initiate, then after a few thrusts would withdraw saying "no, I just can't". It moved on to abusive behavior. Demanded oral sex and started saying things like "hurt me" while pushing my head down and not letting me get away. Next day he took my hand and told me again to "hurt" him and to rip his penis off while squeezing my hand so hard I couldn't make a fist for a week. There were other things, but you get the idea. So, from my experience I would say that depression changes everything---even sex.